Opioids and constipation

In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile.

BACKGROUND AND PURPOSE For patients experiencing inadequate analgesia and intolerable opioid-related side effects on one strong opioid analgesic, pain relief with acceptable tolerability is often achieved by rotation to a second strong opioid. These observations suggest subtle pharmacodynamic differences between opioids in vivo. This study in rats was designed to assess differences between opio...

Constipation

Bigg, p.r.c.s.e. London : Balliere, Tindall it Cox, 1902. Pp. 67. Cr. 8vo. Price, 2s. 6d. This is an admirable little book describing in simple language constipation, its causation, widespread prevalence and its treatment. Constipation is a complaint which is not confined to one class nor any one age, it affects all classes of men, women and children. Our author is very sound in his advice, and...

Challenges and New Treatment in Childhood Constipation

Chronic Constipation is a debilitating condition that is often associated with different abdominal problem. It can cause distress for the child and family and can result in emotional disturbance and family problem. Based on the current algorhytm, the treatment of chronic constipation consists of 4 important phases, 1: education, 2: disimpaction, 3: prevention of re-accumulation of feces and 4: ...

Constipation and herbal medicine

Constipation is characterized by a variety of bowel symptoms such as difficulty passing stool, hard stool, and a feeling of incomplete evacuation. The multifactorial causes of constipation limit the clinical efficacy of current conventional treatments that use a single drug that acts through only one pathway. To complement the shortcomings of the current Western medical model and provide a comp...

Constipation: definition and classification.